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Attention Score in Context
| Title |
A quantitative review of the postmortem evidence for decreased cortical N-methyl-d-aspartate receptor expression levels in schizophrenia: How can we link molecular abnormalities to mismatch negativity deficits?
|
|---|---|
| Published in |
Biological Psychology, November 2015
|
| DOI | 10.1016/j.biopsycho.2015.10.013 |
| Pubmed ID | |
| Authors |
Vibeke S. Catts, Yan Ling Lai, Cyndi Shannon Weickert, Thomas W. Weickert, Stanley V. Catts |
| Abstract |
Evidence suggests that anomalous mismatch negativity (MMN) in schizophrenia is related to glutamatergic abnormalities, possibly involving N-methyl-D-aspartate (NMDA) receptors. Decreased cortical expressions of NMDA receptor subunits have been observed in schizophrenia, though not consistently. To aid with integration and interpretation of previous work, we performed a meta-analysis of effect sizes of mRNA or protein levels of the obligatory NR1 subunit in prefrontal cortex from people with schizophrenia. In schizophrenia compared to unaffected controls the pooled effect size was -0.64 (95% confidence interval: -1.08 to -0.20) for NR1 mRNA reduction and -0.44 (95% confidence interval: -0.80 to -0.07) for NR1 protein reduction. These results represent the first step to a deeper understanding of the region-specific, cell-specific, and stage-specific NMDA receptor hypofunction in schizophrenia, which could be linked to mismatch negativity deficits via transgenic and pharmacological animal models. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 1% |
| United States | 1 | <1% |
| Unknown | 196 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 14% |
| Student > Master | 27 | 14% |
| Student > Ph. D. Student | 26 | 13% |
| Student > Bachelor | 24 | 12% |
| Student > Doctoral Student | 15 | 8% |
| Other | 33 | 17% |
| Unknown | 47 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 54 | 27% |
| Medicine and Dentistry | 27 | 14% |
| Psychology | 21 | 11% |
| Agricultural and Biological Sciences | 14 | 7% |
| Biochemistry, Genetics and Molecular Biology | 6 | 3% |
| Other | 18 | 9% |
| Unknown | 59 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2019.
All research outputs
#6,930,354
of 25,374,917 outputs
Outputs from Biological Psychology
#579
of 1,806 outputs
Outputs of similar age
#79,666
of 294,330 outputs
Outputs of similar age from Biological Psychology
#7
of 32 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,806 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,330 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.