| Title |
Normocaloric versus hypocaloric feeding on the outcomes of ICU patients: a systematic review and meta-analysis
|
|---|---|
| Published in |
Intensive Care Medicine, March 2016
|
| DOI | 10.1007/s00134-015-4131-4 |
| Pubmed ID | |
| Authors |
Paul E. Marik, Michael H. Hooper |
| Abstract |
Current clinical practice guidelines recommend providing ICU patients a daily caloric intake estimated to match 80-100 % of energy expenditure (normocaloric goals). However, recent clinical trials of intentional hypocaloric feeding question this approach. We performed a systematic review and meta-analysis to compare the outcomes of ICU patients randomized to intentional hypocaloric or normocaloric goals. We included randomized controlled trials that enrolled ICU patients and compared intentional hypocaloric with normocaloric nutritional goals. We included studies that evaluated both trophic feeding as well as permissive underfeeding. Data sources included MEDLINE, Cochrane Register of Controlled Trials and citation review of relevant primary and review articles. The outcomes of interest included hospital acquired infection, hospital mortality, ICU length of stay (LOS) and ventilator-free days (VFDs). Six studies which enrolled 2517 patients met our inclusion criteria. The mean age and body mass index (BMI) across the studies were 53 ± 5 years and 29.1 ± 1.5 kg/m(2), respectively. Two studies compared normocaloric feeding (77 % of goal) with trophic feeding (20 % of goal), while four studies compared normocaloric feeding (72 % of goal) with permissive underfeeding (49 % of goal). Overall, there was no significant difference in the risk of infectious complications (OR 1.03; 95 % CI 0.84-1.27, I (2) = 16 %), hospital mortality (OR 0.91; 95 % CI 0.75-1.11, I (2) = 8 %) or ICU LOS (mean difference 0.05 days; 95 % CI 1.33-1.44 days; I (2) = 37 %) between groups. VFDs were reported in three studies with no significant difference between the normocaloric and intentional hypocaloric groups (data not pooled). This meta-analysis demonstrated no difference in the risk of acquired infections, hospital mortality, ICU length of stay or ventilator-free days between patients receiving intentional hypocaloric as compared to normocaloric nutritional goals. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 38% |
| Spain | 2 | 25% |
| Malaysia | 1 | 13% |
| Venezuela, Bolivarian Republic of | 1 | 13% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 38% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Egypt | 1 | <1% |
| Unknown | 169 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 16% |
| Researcher | 25 | 15% |
| Other | 20 | 12% |
| Student > Postgraduate | 17 | 10% |
| Student > Bachelor | 12 | 7% |
| Other | 39 | 23% |
| Unknown | 31 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 92 | 53% |
| Nursing and Health Professions | 22 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Social Sciences | 3 | 2% |
| Biochemistry, Genetics and Molecular Biology | 2 | 1% |
| Other | 11 | 6% |
| Unknown | 37 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2023.
All research outputs
#2,152,833
of 24,761,242 outputs
Outputs from Intensive Care Medicine
#1,671
of 5,302 outputs
Outputs of similar age
#33,907
of 304,233 outputs
Outputs of similar age from Intensive Care Medicine
#17
of 126 outputs
Altmetric has tracked 24,761,242 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,302 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
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We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.