Title |
APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population
|
---|---|
Published in |
Journal of Human Genetics, November 2015
|
DOI | 10.1038/jhg.2015.136 |
Pubmed ID | |
Authors |
Taeko K Naruse, Daisuke Sakurai, Hitoshi Ohtani, Gaurav Sharma, Surendra K Sharma, Madhu Vajpayee, Narinder K Mehra, Gurvinder Kaur, Akinori Kimura |
Abstract |
Human APOBEC3H (A3H) is a member of APOBEC cytidine deaminase family intensively constraining the HIV-1 replication. A3H is known to be polymorphic with different protein stability and anti-HIV-1 activity in vitro. We recently reported that A3H haplotypes composed of two functional polymorphisms, rs139292 (N15del) and rs139297 (G105R), were associated with the susceptibility to HIV-1 infection in Japanese. To confirm the association of A3H and HIV-1 infection in another ethnic group, a total of 241 HIV-1-infected Indian individuals and ethnic-matched 286 healthy controls were analyzed for the A3H polymorphisms. The frequency of 15del allele was high in the HIV-1-infected subjects as compared with the controls (0.477 vs 0.402, odds ratio (OR)=1.36, P=0.014). Haplotype analysis showed that the frequencies of 15del-105R was high (0.475 vs 0.400, OR=1.36, permutation P=0.037) in the HIV-1-infected subjects, confirming the association of A3H polymorphisms with the susceptibility to HIV-1 infection.Journal of Human Genetics advance online publication, 12 November 2015; doi:10.1038/jhg.2015.136. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 19% |
Professor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Researcher | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Immunology and Microbiology | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Social Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 31% |