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Identification of Iron Homeostasis Genes Dysregulation Potentially Involved in Retinopathy of Prematurity Pathogenicity by Microarray Analysis

Overview of attention for article published in Journal of Ophthalmology, October 2015
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Title
Identification of Iron Homeostasis Genes Dysregulation Potentially Involved in Retinopathy of Prematurity Pathogenicity by Microarray Analysis
Published in
Journal of Ophthalmology, October 2015
DOI 10.1155/2015/584854
Pubmed ID
Authors

Xian-qiong Luo, Chun-yi Zhang, Jia-wen Zhang, Jing-bo Jiang, Ai-hua Yin, Li Guo, Chuan Nie, Xu-zai Lu, Hua Deng, Liang Zhang

Abstract

Retinopathy of prematurity (ROP) is a serious disease of preterm neonates and there are limited systematic studies of the molecular mechanisms underlying ROP. Therefore, here we performed global gene expression profiling in human fetal retinal microvascular endothelial cells (RMECs) under hypoxic conditions in vitro. Aborted fetuses were enrolled and primary RMECs were isolated from eyeballs. Cultivated cells were treated with CoCl2 to induce hypoxia. The dual-color microarray approach was adopted to compare gene expression profiling between treated RMECs and the paired untreated control. The one-class algorithm in significance analysis of microarray (SAM) software was used to screen the differentially expressed genes (DEGs) and quantitative RT-PCR (qRT-PCR) was conducted to validate the results. Gene Ontology was employed for functional enrichment analysis. There were 326 DEGs between the hypoxia-induced group and untreated group. Of these genes, 198 were upregulated in hypoxic RMECs, while the other 128 hits were downregulated. In particular, genes in the iron ion homeostasis pathway were highly enriched under hypoxic conditions. Our study indicates that dysregulation of genes involved in iron homeostasis mediating oxidative damage may be responsible for the mechanisms underlying ROP. The "oxygen plus iron" hypothesis may improve our understanding of ROP pathogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 23%
Student > Master 2 15%
Student > Doctoral Student 1 8%
Professor 1 8%
Student > Bachelor 1 8%
Other 2 15%
Unknown 3 23%
Readers by discipline Count As %
Medicine and Dentistry 6 46%
Biochemistry, Genetics and Molecular Biology 1 8%
Veterinary Science and Veterinary Medicine 1 8%
Agricultural and Biological Sciences 1 8%
Nursing and Health Professions 1 8%
Other 0 0%
Unknown 3 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Journal of Ophthalmology
#543
of 956 outputs
Outputs of similar age
#216,533
of 295,592 outputs
Outputs of similar age from Journal of Ophthalmology
#39
of 87 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 956 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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