| Title |
Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?
|
|---|---|
| Published in |
Clinical Oral Investigations, November 2015
|
| DOI | 10.1007/s00784-015-1646-6 |
| Pubmed ID | |
| Authors |
Jinxiu Zhang, Xiaojing Huang, Bingling Lu, Chengfei Zhang, Zhiyu Cai |
| Abstract |
The aim of this study was to investigate whether apical periodontitis (AP) could cause systemic cytokine elevation and pathological changes in remote organs in an experimental animal model. AP was induced in 36 Sprague Dawley (SD) rats. Serum levels of C-reactive protein (CRP), interleukin 2 (IL-2), and interleukin 6 (IL-6) were measured by enzyme-linked immunosorbent assays at different time intervals (0, 6, 12, 24, 48, and 96 h and 1, 2, 3, 4, 5, and 6 weeks) after pulp exposure. Multiple organs (the aortic arch, myocardium, liver, and spleen) were collected for histological observation. The results were analyzed by one-way analysis of variance (ANOVA). Serum levels of CRP, IL-2, and IL-6 were significantly elevated at all time points assessed after 6, 24, and 96 h, respectively. The peak values of serum cytokines (CRP 6.363 ± 0.05 ng/ml, IL-2 21.997 ± 0.15 ng/L, and IL-6 2.406 ± 0.02 ng/L) were reached at 1, 4, and 2 weeks, respectively, followed by a decline. Time-dependent reversible histopathological changes were detected in the aortic arch, myocardium, and spleen, whereas irreversible changes were found in the liver. AP elevated the levels of CRP, IL-2, and IL-6 in rat blood serum, causing reversible changes in the aortic arch, myocardium, and spleen as well as irreversible changes in the liver. AP may trigger a systemic immune response, impair remote organs, and affect the general health of patients. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 9% |
| Professor > Associate Professor | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Researcher | 5 | 8% |
| Student > Postgraduate | 3 | 5% |
| Other | 14 | 22% |
| Unknown | 24 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 44% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Unspecified | 1 | 2% |
| Business, Management and Accounting | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 27 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2015.
All research outputs
#20,295,501
of 22,832,057 outputs
Outputs from Clinical Oral Investigations
#1,019
of 1,408 outputs
Outputs of similar age
#236,863
of 282,792 outputs
Outputs of similar age from Clinical Oral Investigations
#24
of 31 outputs
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