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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, June 2010
|
| DOI | 10.1073/pnas.1000097107 |
| Pubmed ID | |
| Authors |
Marcus J. Claesson, Siobhán Cusack, Orla O'Sullivan, Rachel Greene-Diniz, Heleen de Weerd, Edel Flannery, Julian R. Marchesi, Daniel Falush, Timothy Dinan, Gerald Fitzgerald, Catherine Stanton, Douwe van Sinderen, Michael O'Connor, Norma Harnedy, Kieran O'Connor, Colm Henry, Denis O'Mahony, Anthony P. Fitzgerald, Fergus Shanahan, Cillian Twomey, Colin Hill, R. Paul Ross, Paul W. O'Toole |
| Abstract |
Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and Faecalibacteria. The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,520 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | <1% |
| United Kingdom | 6 | <1% |
| Spain | 5 | <1% |
| Denmark | 3 | <1% |
| Italy | 3 | <1% |
| Netherlands | 2 | <1% |
| France | 2 | <1% |
| Korea, Republic of | 2 | <1% |
| Germany | 2 | <1% |
| Other | 12 | <1% |
| Unknown | 1469 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 245 | 16% |
| Student > Ph. D. Student | 244 | 16% |
| Student > Master | 215 | 14% |
| Student > Bachelor | 195 | 13% |
| Student > Doctoral Student | 71 | 5% |
| Other | 229 | 15% |
| Unknown | 321 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 412 | 27% |
| Biochemistry, Genetics and Molecular Biology | 203 | 13% |
| Medicine and Dentistry | 190 | 13% |
| Immunology and Microbiology | 114 | 8% |
| Nursing and Health Professions | 43 | 3% |
| Other | 185 | 12% |
| Unknown | 373 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2021.
All research outputs
#941,132
of 26,017,215 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#14,715
of 104,451 outputs
Outputs of similar age
#2,666
of 108,006 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#54
of 708 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 104,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,006 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 708 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.