| Title |
Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair
|
|---|---|
| Published in |
Stem Cell Research & Therapy, November 2015
|
| DOI | 10.1186/s13287-015-0214-y |
| Pubmed ID | |
| Authors |
Takeshi Katsuda, Takahiro Ochiya |
| Abstract |
Extracellular vesicles (EVs) play important roles in intercellular communications via their content molecules, and mimic, at least in part, the roles that are played by their originating cells. Consistent with this notion, an increasing number of reports have suggested that EVs derived from mesenchymal stem cells (MSCs), which are therapeutically beneficial to a wide range of diseases, can serve as drugs to treat multiple diseases. EVs contain a variety of molecules, including proteins, microRNAs, and mRNAs, and are associated with biological processes in a content molecule-dependent manner. In this article, we review the latest reports regarding the therapeutic potential of MSC-EVs by focusing on the underlying molecular mechanisms of their effects. Specifically, we feature the effects of MSC-EVs in terms of their content molecules and of the tissue recovery processes endowed by these molecules. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 128 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 20% |
| Researcher | 25 | 19% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 6 | 5% |
| Other | 16 | 12% |
| Unknown | 27 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 18% |
| Medicine and Dentistry | 24 | 18% |
| Agricultural and Biological Sciences | 22 | 17% |
| Neuroscience | 7 | 5% |
| Immunology and Microbiology | 4 | 3% |
| Other | 15 | 12% |
| Unknown | 34 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2016.
All research outputs
#12,878,242
of 22,832,057 outputs
Outputs from Stem Cell Research & Therapy
#854
of 2,420 outputs
Outputs of similar age
#124,607
of 282,576 outputs
Outputs of similar age from Stem Cell Research & Therapy
#27
of 60 outputs
Altmetric has tracked 22,832,057 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,420 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,576 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.