| Title |
MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer
|
|---|---|
| Published in |
Tumor Biology, November 2015
|
| DOI | 10.1007/s13277-015-4374-2 |
| Pubmed ID | |
| Authors |
Lingling Guo, Yongsheng Zhang, Lifeng Zhang, Fengbo Huang, Jinfan Li, Shouli Wang |
| Abstract |
Inflammatory cells and mediators form a major part of the tumor microenvironment and play important roles in the regulation of cancer initiation, tumor cell proliferation, and metastasis. MicroRNAs (miRNAs) play important roles in several physiological and pathological processes, including the regulation of the inflammatory microenvironment in cancer. Transforming growth factor-β (TGF-β) is an inflammation-related cytokine that functions in both tumor suppression and promotion; however, its underlying molecular mechanisms remain unclear. Recent evidence indicates an association between miRNAs and TGF-β signaling, providing new insight into the nature of the inflammatory microenvironment in cancer. The present review is an overview of the interaction between miRNAs and inflammatory cytokines, with emphasis on the cross talk between TGF-β signaling and miRNAs and their influence on cancer cell behavior. The emerging roles of miRNAs in cancer-related inflammation and the potential to target miRNA signaling pathways for cancer therapy are also discussed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Egypt | 1 | 1% |
| Unknown | 94 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 23% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 12 | 13% |
| Student > Doctoral Student | 5 | 5% |
| Other | 16 | 17% |
| Unknown | 14 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 36% |
| Medicine and Dentistry | 17 | 18% |
| Agricultural and Biological Sciences | 10 | 10% |
| Immunology and Microbiology | 5 | 5% |
| Computer Science | 2 | 2% |
| Other | 10 | 10% |
| Unknown | 17 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2023.
All research outputs
#16,130,979
of 24,541,341 outputs
Outputs from Tumor Biology
#1,024
of 2,644 outputs
Outputs of similar age
#161,642
of 288,123 outputs
Outputs of similar age from Tumor Biology
#64
of 304 outputs
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So far Altmetric has tracked 2,644 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
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We're also able to compare this research output to 304 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.