Title |
Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population
|
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Published in |
Journal of Autism and Developmental Disorders, September 2018
|
DOI | 10.1007/s10803-018-3743-2 |
Pubmed ID | |
Authors |
Troy Vargason, Deborah L. McGuinness, Juergen Hahn |
Abstract |
A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 22% |
Venezuela, Bolivarian Republic of | 1 | 11% |
Spain | 1 | 11% |
Argentina | 1 | 11% |
United States | 1 | 11% |
Canada | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 97 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 23% |
Student > Ph. D. Student | 11 | 11% |
Researcher | 10 | 10% |
Student > Bachelor | 9 | 9% |
Student > Doctoral Student | 5 | 5% |
Other | 7 | 7% |
Unknown | 33 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 13% |
Nursing and Health Professions | 10 | 10% |
Psychology | 8 | 8% |
Biochemistry, Genetics and Molecular Biology | 7 | 7% |
Neuroscience | 6 | 6% |
Other | 18 | 19% |
Unknown | 35 | 36% |