Title |
Recent advances in the development of subunit-based RSV vaccines
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Published in |
Expert Review of Vaccines, October 2015
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DOI | 10.1586/14760584.2016.1105134 |
Pubmed ID | |
Authors |
Noushin Jaberolansar, Istvan Toth, Paul R Young, Mariusz Skwarczynski |
Abstract |
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections causing pneumonia and bronchiolitis in infants. RSV also causes serious illness in elderly populations, immunocompromised patients and individuals with pulmonary or cardiac problems. The significant morbidity and mortality associated with RSV infection have prompted interest in RSV vaccine development. In the 1960s, a formalin-inactivated vaccine trial failed to protect children, and indeed enhanced pathology when naturally infected later with RSV. Hence, an alternative approach to traditional killed virus vaccines, which can induce protective immunity without serious adverse events, is desired. Several strategies have been explored in attempts to produce effective vaccine candidates including gene-based and subunit vaccines. Subunit-based vaccine approaches have shown promising efficacy in animal studies and several have reached clinical trials. The current stage of development of subunit-based vaccines against RSV is reviewed in this article. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 19% |
Student > Ph. D. Student | 11 | 16% |
Student > Bachelor | 7 | 10% |
Student > Master | 6 | 9% |
Student > Postgraduate | 3 | 4% |
Other | 11 | 16% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 25% |
Immunology and Microbiology | 7 | 10% |
Agricultural and Biological Sciences | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 10 | 15% |
Unknown | 20 | 29% |