| Title |
A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice
|
|---|---|
| Published in |
GeroScience, November 2011
|
| DOI | 10.1007/s11357-011-9325-2 |
| Pubmed ID | |
| Authors |
Vadim Aksenov, Jiangang Long, Jiankang Liu, Henry Szechtman, Parul Khanna, Sarthak Matravadia, C. David Rollo |
| Abstract |
We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 29% |
| Researcher | 14 | 23% |
| Student > Master | 4 | 6% |
| Other | 3 | 5% |
| Professor | 3 | 5% |
| Other | 12 | 19% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 23% |
| Neuroscience | 9 | 15% |
| Medicine and Dentistry | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Psychology | 7 | 11% |
| Other | 4 | 6% |
| Unknown | 11 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2017.
All research outputs
#2,964,593
of 25,374,647 outputs
Outputs from GeroScience
#379
of 1,595 outputs
Outputs of similar age
#21,606
of 246,434 outputs
Outputs of similar age from GeroScience
#11
of 25 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,595 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,434 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.