| Title |
Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia
|
|---|---|
| Published in |
JACC: Basic to Translational Science, August 2018
|
| DOI | 10.1016/j.jacbts.2018.05.005 |
| Pubmed ID | |
| Authors |
Travis R. Sexton, Guoying Zhang, Tracy E. Macaulay, Leigh A. Callahan, Richard Charnigo, Olga A. Vsevolozhskaya, Zhenyu Li, Susan Smyth |
| Abstract |
Despite treatment advances for sepsis and pneumonia, significant improvements in outcome have not been realized. Antiplatelet therapy may improve outcome in pneumonia and sepsis. In this study, the authors show that ticagrelor reduced leukocytes with attached platelets as well as the inflammatory biomarker interleukin (IL)-6. Pneumonia patients receiving ticagrelor required less supplemental oxygen and lung function tests trended toward improvement. Disruption of the P2Y12 receptor in a murine model protected against inflammatory response, lung permeability, and mortality. Results indicate a mechanistic link between platelets, leukocytes, and lung injury in settings of pneumonia and sepsis, and suggest possible therapeutic approaches to reduce complications.(Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor [XANTHIPPE]; NCT01883869). |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| United Kingdom | 2 | 9% |
| France | 2 | 9% |
| Pakistan | 1 | 5% |
| Italy | 1 | 5% |
| Egypt | 1 | 5% |
| Montenegro | 1 | 5% |
| Unknown | 11 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 68% |
| Scientists | 4 | 18% |
| Science communicators (journalists, bloggers, editors) | 2 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 14% |
| Student > Master | 8 | 11% |
| Student > Postgraduate | 5 | 7% |
| Researcher | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 31 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 31% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Nursing and Health Professions | 3 | 4% |
| Business, Management and Accounting | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 34 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2021.
All research outputs
#1,645,468
of 25,385,509 outputs
Outputs from JACC: Basic to Translational Science
#147
of 799 outputs
Outputs of similar age
#33,927
of 344,178 outputs
Outputs of similar age from JACC: Basic to Translational Science
#4
of 16 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.