↓ Skip to main content

Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

Overview of attention for article published in Cell Stem Cell, December 2011
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

blogs
1 blog
twitter
8 X users
patent
3 patents
facebook
1 Facebook page
f1000
1 research highlight platform

Citations

dimensions_citation
348 Dimensions

Readers on

mendeley
314 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Published in
Cell Stem Cell, December 2011
DOI 10.1016/j.stem.2011.10.002
Pubmed ID
Authors

James J.H. Chong, Vashe Chandrakanthan, Munira Xaymardan, Naisana S. Asli, Joan Li, Ishtiaq Ahmed, Corey Heffernan, Mary K. Menon, Christopher J. Scarlett, Amirsalar Rashidianfar, Christine Biben, Hans Zoellner, Emily K. Colvin, John E. Pimanda, Andrew V. Biankin, Bin Zhou, William T. Pu, Owen W.J. Prall, Richard P. Harvey

Abstract

Colony-forming units - fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 314 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Germany 3 <1%
Japan 3 <1%
Australia 1 <1%
Brazil 1 <1%
Italy 1 <1%
Spain 1 <1%
Netherlands 1 <1%
Mexico 1 <1%
Other 1 <1%
Unknown 296 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 89 28%
Researcher 70 22%
Student > Master 34 11%
Student > Bachelor 22 7%
Student > Doctoral Student 16 5%
Other 48 15%
Unknown 35 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 110 35%
Biochemistry, Genetics and Molecular Biology 76 24%
Medicine and Dentistry 49 16%
Engineering 10 3%
Chemistry 3 <1%
Other 21 7%
Unknown 45 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2022.
All research outputs
#1,617,119
of 25,374,647 outputs
Outputs from Cell Stem Cell
#1,025
of 2,823 outputs
Outputs of similar age
#10,431
of 246,218 outputs
Outputs of similar age from Cell Stem Cell
#7
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,218 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.