Title |
Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
|
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Published in |
Cell Stem Cell, December 2011
|
DOI | 10.1016/j.stem.2011.10.002 |
Pubmed ID | |
Authors |
James J.H. Chong, Vashe Chandrakanthan, Munira Xaymardan, Naisana S. Asli, Joan Li, Ishtiaq Ahmed, Corey Heffernan, Mary K. Menon, Christopher J. Scarlett, Amirsalar Rashidianfar, Christine Biben, Hans Zoellner, Emily K. Colvin, John E. Pimanda, Andrew V. Biankin, Bin Zhou, William T. Pu, Owen W.J. Prall, Richard P. Harvey |
Abstract |
Colony-forming units - fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
Australia | 1 | 13% |
Austria | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Germany | 3 | <1% |
Japan | 3 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Italy | 1 | <1% |
Spain | 1 | <1% |
Netherlands | 1 | <1% |
Mexico | 1 | <1% |
Other | 1 | <1% |
Unknown | 296 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 89 | 28% |
Researcher | 70 | 22% |
Student > Master | 34 | 11% |
Student > Bachelor | 22 | 7% |
Student > Doctoral Student | 16 | 5% |
Other | 48 | 15% |
Unknown | 35 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 110 | 35% |
Biochemistry, Genetics and Molecular Biology | 76 | 24% |
Medicine and Dentistry | 49 | 16% |
Engineering | 10 | 3% |
Chemistry | 3 | <1% |
Other | 21 | 7% |
Unknown | 45 | 14% |