| Title |
Structure-Activity Studies on Therapeutic Potential of Thymoquinone Analogs in Pancreatic Cancer
|
|---|---|
| Published in |
Pharmaceutical Research, April 2010
|
| DOI | 10.1007/s11095-010-0145-3 |
| Pubmed ID | |
| Authors |
Sanjeev Banerjee, Asfar S. Azmi, Subhash Padhye, Marjit W. Singh, Jubaraj B. Baruah, Philip A. Philip, Fazlul H. Sarkar, Ramzi M. Mohammad |
| Abstract |
Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoquinone (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the concentration of TQ required was considered to be high to show this efficacy. Therefore, novel analogs of TQ with lower IC(50) are highly desirable. We have synthesized a series of 27 new analogs of TQ by modifications at the carbonyl sites or the benzenoid sites using single pot synthesis and tested their biological activity in PC cells. Among these compounds, TQ-2G, TQ-4A1 and TQ-5A1 (patent pending) were found to be more potent than TQ in terms of inhibition of cell growth, induction of apoptosis and modulation of transcription factor-NF-kappaB. We also found that our novel analogs were able to sensitize gemcitabine and oxaliplatin-induced apoptosis in MiaPaCa-2 (gemcitabine resistant) PC cells, which was associated with down-regulation of Bcl-2, Bcl-xL, survivin, XIAP, COX-2 and the associated Prostaglandin E2. From our results, we conclude that three of our novel TQ analogs warrant further investigation against PC, especially in combination with conventional chemotherapeutic agents. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| New Zealand | 1 | 2% |
| India | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Unknown | 58 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 23% |
| Researcher | 11 | 18% |
| Professor > Associate Professor | 6 | 10% |
| Student > Bachelor | 4 | 6% |
| Professor | 4 | 6% |
| Other | 10 | 16% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 21% |
| Chemistry | 8 | 13% |
| Agricultural and Biological Sciences | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Engineering | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 16 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2021.
All research outputs
#6,292,480
of 22,833,393 outputs
Outputs from Pharmaceutical Research
#914
of 2,857 outputs
Outputs of similar age
#29,883
of 95,662 outputs
Outputs of similar age from Pharmaceutical Research
#17
of 44 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,857 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.