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Antidotes for poisoning by alcohols that form toxic metabolites

Overview of attention for article published in British Journal of Clinical Pharmacology, January 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
3 news outlets
twitter
24 X users
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
3 YouTube creators

Citations

dimensions_citation
101 Dimensions

Readers on

mendeley
166 Mendeley
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1 CiteULike
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Title
Antidotes for poisoning by alcohols that form toxic metabolites
Published in
British Journal of Clinical Pharmacology, January 2016
DOI 10.1111/bcp.12824
Pubmed ID
Authors

Kenneth McMartin, Dag Jacobsen, Knut Erik Hovda

Abstract

The alcohols, methanol, ethylene glycol and diethylene glycol, have many features in common, the most important of which is the fact that the compounds themselves are relatively nontoxic but are metabolized, initially by alcohol dehydrogenase, to various toxic intermediates. These compounds are readily available worldwide in commercial products as well as in homemade alcoholic beverages, both of which lead to most of the poisoning cases, from either unintentional or intentional ingestion. Although relatively infrequent in overall occurence, poisonings by metabolically-toxic alcohols do unfortunately occur in outbreaks and can result in severe morbidity and mortality. These poisonings have traditionally been treated with ethanol since it competes for the active site of alcohol dehydrogenase and decreases the formation of toxic metabolites. Although ethanol can be effective in these poisonings, there are substantial practical problems with its use and so fomepizole, a potent competitive inhibitor of alcohol dehydrogenase, was developed for a hopefully better treatment for metabolically-toxic alcohol poisonings. Fomepizole has few side effects and is easy to use in practice and it may obviate the need for haemodialysis in some, but not all, patients. Hence, fomepizole has largely replaced ethanol as the toxic alcohol antidote in many countries. Nevertheless, ethanol remains an important alternative because access to fomepizole can be limited, the cost may appear excessive, or the physician may prefer ethanol due to experience.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 165 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 15%
Student > Postgraduate 23 14%
Other 13 8%
Student > Ph. D. Student 11 7%
Researcher 11 7%
Other 37 22%
Unknown 46 28%
Readers by discipline Count As %
Medicine and Dentistry 65 39%
Pharmacology, Toxicology and Pharmaceutical Science 18 11%
Agricultural and Biological Sciences 9 5%
Biochemistry, Genetics and Molecular Biology 9 5%
Chemistry 4 2%
Other 12 7%
Unknown 49 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2022.
All research outputs
#985,836
of 25,123,616 outputs
Outputs from British Journal of Clinical Pharmacology
#248
of 5,472 outputs
Outputs of similar age
#17,271
of 405,318 outputs
Outputs of similar age from British Journal of Clinical Pharmacology
#3
of 57 outputs
Altmetric has tracked 25,123,616 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,472 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.