| Title |
Advances in synthetic biology of oleaginous yeast Yarrowia lipolytica for producing non-native chemicals
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, May 2018
|
| DOI | 10.1007/s00253-018-9099-x |
| Pubmed ID | |
| Authors |
Farshad Darvishi, Mehdi Ariana, Eko Roy Marella, Irina Borodina |
| Abstract |
Oleaginous yeast Yarrowia lipolytica is an important industrial host for the production of enzymes, oils, fragrances, surfactants, cosmetics, and pharmaceuticals. More recently, improved synthetic biology tools have allowed more extensive engineering of this yeast species, which lead to the production of non-native metabolites. In this review, we summarize the recent advances of genome editing tools for Y. lipolytica, including the application of CRISPR/Cas9 system and discuss case studies, where Y. lipolytica was engineered to produce various non-native chemicals: short-chain fatty alcohols and alkanes as biofuels, polyunsaturated fatty acids for nutritional and pharmaceutical applications, polyhydroxyalkanoates and dicarboxylic acids as precursors for biodegradable plastics, carotenoid-type pigments for food and feed, and campesterol as a precursor for steroid drugs. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 17% |
| Researcher | 14 | 12% |
| Student > Ph. D. Student | 14 | 12% |
| Student > Bachelor | 12 | 10% |
| Student > Doctoral Student | 7 | 6% |
| Other | 13 | 11% |
| Unknown | 41 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 30% |
| Agricultural and Biological Sciences | 22 | 18% |
| Chemical Engineering | 6 | 5% |
| Engineering | 2 | 2% |
| Immunology and Microbiology | 1 | <1% |
| Other | 9 | 7% |
| Unknown | 45 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#19,611,252
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#6,478
of 8,034 outputs
Outputs of similar age
#260,113
of 335,086 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#96
of 153 outputs
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