| Title |
Cellular switches orchestrate rhythmic circuits
|
|---|---|
| Published in |
Biological Cybernetics, September 2018
|
| DOI | 10.1007/s00422-018-0778-6 |
| Pubmed ID | |
| Authors |
Guillaume Drion, Alessio Franci, Rodolphe Sepulchre |
| Abstract |
Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the circuit rhythms entirely rely on specific tunings of the synaptic connectivity, which makes them rigid, fragile, and difficult to control externally. We illustrate those properties on the much studied architecture of a small network controlling both the pyloric and gastric rhythms of crabs. The cellular switch is provided by a slow negative conductance often neglected in mathematical modeling of central pattern generators. We propose that this conductance is simple to model and key to computational studies of rhythmic circuit neuromodulation. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 24% |
| Researcher | 4 | 24% |
| Other | 2 | 12% |
| Professor | 1 | 6% |
| Student > Master | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 29% |
| Engineering | 3 | 18% |
| Biochemistry, Genetics and Molecular Biology | 2 | 12% |
| Computer Science | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
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#20,532,290
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Outputs from Biological Cybernetics
#641
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Outputs of similar age from Biological Cybernetics
#5
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