↓ Skip to main content

Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

Overview of attention for article published in eLife, November 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
1 news outlet
twitter
19 X users
facebook
3 Facebook pages

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
99 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila
Published in
eLife, November 2015
DOI 10.7554/elife.08501
Pubmed ID
Authors

Susumu Hirabayashi, Ross L Cagan

Abstract

Cancer cells demand excessive nutrients to support their proliferation but how cancer cells sense and promote growth in the nutrient favorable conditions remain incompletely understood. Epidemiological studies have indicated that obesity is a risk factor for various types of cancers. Feeding Drosophila a high dietary sugar was previously demonstrated to not only direct metabolic defects including obesity and organismal insulin resistance, but also transform Ras/Src-activated cells into aggressive tumors. Here we demonstrate that Ras/Src-activated cells are sensitive to perturbations in the Hippo signaling pathway. We provide evidence that nutritional cues activate Salt-inducible kinase, leading to Hippo pathway downregulation in Ras/Src-activated cells. The result is Yorkie-dependent increase in Wingless signaling, a key mediator that promotes diet-enhanced Ras/Src-tumorigenesis in an otherwise insulin-resistant environment. Through this mechanism, Ras/Src-activated cells are positioned to efficiently respond to nutritional signals and ensure tumor growth upon nutrient rich condition including obesity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Unknown 97 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 26%
Student > Ph. D. Student 18 18%
Student > Master 11 11%
Student > Bachelor 8 8%
Professor 6 6%
Other 14 14%
Unknown 16 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 36%
Biochemistry, Genetics and Molecular Biology 30 30%
Medicine and Dentistry 7 7%
Immunology and Microbiology 2 2%
Neuroscience 2 2%
Other 6 6%
Unknown 16 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#1,912,083
of 23,577,654 outputs
Outputs from eLife
#5,716
of 14,362 outputs
Outputs of similar age
#33,254
of 389,785 outputs
Outputs of similar age from eLife
#81
of 297 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,362 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.8. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,785 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 297 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.