Title |
Paracingulate sulcus morphology is associated with hallucinations in the human brain
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Published in |
Nature Communications, November 2015
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DOI | 10.1038/ncomms9956 |
Pubmed ID | |
Authors |
Jane R. Garrison, Charles Fernyhough, Simon McCarthy-Jones, Mark Haggard, Jon S. Simons |
Abstract |
Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1 cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 25 | 19% |
United States | 16 | 12% |
Spain | 8 | 6% |
Canada | 6 | 5% |
Germany | 2 | 2% |
Netherlands | 2 | 2% |
Greece | 2 | 2% |
Ireland | 2 | 2% |
Portugal | 1 | <1% |
Other | 13 | 10% |
Unknown | 55 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 81 | 61% |
Scientists | 30 | 23% |
Practitioners (doctors, other healthcare professionals) | 14 | 11% |
Science communicators (journalists, bloggers, editors) | 7 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Switzerland | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Netherlands | 1 | <1% |
Unknown | 165 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 33 | 19% |
Student > Ph. D. Student | 27 | 16% |
Student > Bachelor | 23 | 13% |
Researcher | 22 | 13% |
Professor | 11 | 6% |
Other | 30 | 18% |
Unknown | 25 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 45 | 26% |
Neuroscience | 34 | 20% |
Medicine and Dentistry | 20 | 12% |
Agricultural and Biological Sciences | 10 | 6% |
Engineering | 4 | 2% |
Other | 16 | 9% |
Unknown | 42 | 25% |