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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A network of autism linked genes stabilizes two pools of synaptic GABAA receptors
|
|---|---|
| Published in |
eLife, November 2015
|
| DOI | 10.7554/elife.09648 |
| Pubmed ID | |
| Authors |
Xia-Jing Tong, Zhitao Hu, Yu Liu, Dorian Anderson, Joshua M Kaplan |
| Abstract |
Changing receptor abundance at synapses is an important mechanism for regulating synaptic strength. Synapses contain two pools of receptors, immobilized and diffusing receptors, both of which are confined to post-synaptic elements. Here we show that immobile and diffusing GABAA receptors are stabilized by distinct synaptic scaffolds at C. elegans neuromuscular junctions. Immobilized GABAA receptors are stabilized by binding to FRM-3/EPB4.1 and LIN-2A/CASK. Diffusing GABAA receptors are stabilized by the synaptic adhesion molecules Neurexin and Neuroligin. Inhibitory post-synaptic currents are eliminated in double mutants lacking both scaffolds. Neurexin, Neuroligin, and CASK mutations are all linked to Autism Spectrum Disorders (ASD). Our results suggest that these mutations may directly alter inhibitory transmission, which could contribute to the developmental and cognitive deficits observed in ASD. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| United States | 1 | 11% |
| Germany | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 30% |
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Professor | 5 | 7% |
| Other | 6 | 9% |
| Unknown | 11 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 33% |
| Agricultural and Biological Sciences | 17 | 25% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Engineering | 2 | 3% |
| Psychology | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 12 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2017.
All research outputs
#685,812
of 22,833,393 outputs
Outputs from eLife
#2,390
of 13,835 outputs
Outputs of similar age
#12,710
of 386,426 outputs
Outputs of similar age from eLife
#45
of 298 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,835 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 298 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.