Title |
Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome
|
---|---|
Published in |
Journal of Neuroimmunology, July 2015
|
DOI | 10.1016/j.jneuroim.2015.06.013 |
Pubmed ID | |
Authors |
Adeline Chan, Jun Yan, Peter Csurhes, Judith Greer, Pamela McCombe |
Abstract |
The aim of this study was to measure the levels of circulating BDNF and the frequency of BDNF-producing T cells after acute ischaemic stroke. Serum BDNF levels were measured by ELISA. Flow cytometry was used to enumerate peripheral blood leukocytes that were labelled with antibodies against markers of T cells, T regulatory cells (Tregs), and intracellular BDNF. There was a slight increase in serum BDNF levels after stroke. There was no overall difference between stroke patients and controls in the frequency of CD4(+) and CD8(+) BDNF(+) cells, although a subgroup of stroke patients showed high frequencies of these cells. However, there was an increase in the percentage of BDNF(+) Treg cells in the CD4(+) population in stroke patients compared to controls. Patients with high percentages of CD4(+) BDNF(+) Treg cells had a better outcome at 6months than those with lower levels. These groups did not differ in age, gender or initial stroke severity. Enhancement of BDNF production after stroke could be a useful means of improving neuroprotection and recovery after stroke. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 17% |
Student > Ph. D. Student | 9 | 15% |
Researcher | 7 | 12% |
Student > Bachelor | 5 | 8% |
Student > Postgraduate | 4 | 7% |
Other | 11 | 18% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 23% |
Neuroscience | 10 | 17% |
Agricultural and Biological Sciences | 5 | 8% |
Immunology and Microbiology | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 8 | 13% |
Unknown | 16 | 27% |