Chapter title |
Glucocorticoids and Skeletal Muscle
|
---|---|
Chapter number | 7 |
Book title |
Glucocorticoid Signaling
|
Published in |
Advances in experimental medicine and biology, November 2015
|
DOI | 10.1007/978-1-4939-2895-8_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2894-1, 978-1-4939-2895-8
|
Authors |
Sue C. Bodine, J. David Furlow, Bodine, Sue C., Furlow, J. David |
Abstract |
Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a catabolic effect that is opposite that of insulin. In many catabolic diseases, such as sepsis, starvation, and cancer cachexia, endogenous glucocorticoids are elevated contributing to the loss of muscle mass and function. Further, exogenous glucocorticoids are often given acutely and chronically to treat inflammatory conditions such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, resulting in muscle atrophy. This chapter will detail the nature of glucocorticoid-induced muscle atrophy and discuss the mechanisms thought to be responsible for the catabolic effects of glucocorticoids on muscle. |
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