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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes
|
|---|---|
| Published in |
Immunity, November 2015
|
| DOI | 10.1016/j.immuni.2015.10.016 |
| Pubmed ID | |
| Authors |
Tiffany C. Scharschmidt, Kimberly S. Vasquez, Hong-An Truong, Sofia V. Gearty, Mariela L. Pauli, Audrey Nosbaum, Iris K. Gratz, Michael Otto, James J. Moon, Jan Liese, Abul K. Abbas, Michael A. Fischbach, Michael D. Rosenblum |
| Abstract |
The skin is a site of constant dialog between the immune system and commensal bacteria. However, the molecular mechanisms that allow us to tolerate the presence of skin commensals without eliciting destructive inflammation are unknown. Using a model system to study the antigen-specific response to S. epidermidis, we demonstrated that skin colonization during a defined period of neonatal life was required for establishing immune tolerance to commensal microbes. This crucial window was characterized by an abrupt influx of highly activated regulatory T (Treg) cells into neonatal skin. Selective inhibition of this Treg cell wave completely abrogated tolerance. Thus, the host-commensal relationship in the skin relied on a unique Treg cell population that mediated tolerance to bacterial antigens during a defined developmental window. This suggests that the cutaneous microbiome composition in neonatal life is crucial in shaping adaptive immune responses to commensals, and disrupting these interactions might have enduring health implications. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 30% |
| United Arab Emirates | 1 | 3% |
| Mexico | 1 | 3% |
| Finland | 1 | 3% |
| Poland | 1 | 3% |
| Switzerland | 1 | 3% |
| Thailand | 1 | 3% |
| Germany | 1 | 3% |
| Italy | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 60% |
| Scientists | 10 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 522 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Singapore | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 513 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 122 | 23% |
| Researcher | 100 | 19% |
| Student > Master | 39 | 7% |
| Student > Bachelor | 37 | 7% |
| Student > Doctoral Student | 23 | 4% |
| Other | 89 | 17% |
| Unknown | 112 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 142 | 27% |
| Agricultural and Biological Sciences | 109 | 21% |
| Biochemistry, Genetics and Molecular Biology | 57 | 11% |
| Medicine and Dentistry | 56 | 11% |
| Neuroscience | 7 | 1% |
| Other | 24 | 5% |
| Unknown | 127 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2023.
All research outputs
#782,369
of 26,017,215 outputs
Outputs from Immunity
#676
of 4,864 outputs
Outputs of similar age
#11,736
of 298,419 outputs
Outputs of similar age from Immunity
#11
of 60 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,419 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.