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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney
|
|---|---|
| Published in |
Nature Communications, November 2015
|
| DOI | 10.1038/ncomms9891 |
| Pubmed ID | |
| Authors |
Angshumoy Roy, Vijetha Kumar, Barry Zorman, Erica Fang, Katherine M. Haines, HarshaVardhan Doddapaneni, Oliver A. Hampton, Simon White, Abhishek A. Bavle, Nimesh R. Patel, Karen W. Eldin, M. John Hicks, Dinesh Rakheja, Patrick J. Leavey, Stephen X. Skapek, James F. Amatruda, Jed G. Nuchtern, Murali M. Chintagumpala, David A. Wheeler, Sharon E. Plon, Pavel Sumazin, D. Williams Parsons |
| Abstract |
The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here we report on the identification of somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR in 23 of 27 (85%) pediatric clear cell sarcomas of the kidney (CCSK) from two independent cohorts. We profile CCSK tumours using a combination of whole-exome, transcriptome and targeted sequencing. Identical ITD mutations are found in primary and relapsed tumour pairs but not in adjacent normal kidney or blood. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours. Transcriptome analysis of ITD-positive CCSKs reveals enrichment for PRC2-regulated genes and similarity to undifferentiated sarcomas harbouring BCOR-CCNB3 fusions. The discovery of recurrent BCOR ITDs defines a major oncogenic event in this childhood sarcoma with significant implications for diagnostic and therapeutic approaches to this tumour. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 50% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Scientists | 3 | 30% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Researcher | 12 | 16% |
| Student > Bachelor | 9 | 12% |
| Other | 6 | 8% |
| Student > Postgraduate | 4 | 5% |
| Other | 15 | 21% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 33% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Agricultural and Biological Sciences | 7 | 10% |
| Unspecified | 2 | 3% |
| Computer Science | 1 | 1% |
| Other | 7 | 10% |
| Unknown | 21 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2016.
All research outputs
#4,180,800
of 23,853,707 outputs
Outputs from Nature Communications
#32,501
of 50,282 outputs
Outputs of similar age
#66,393
of 393,030 outputs
Outputs of similar age from Nature Communications
#412
of 689 outputs
Altmetric has tracked 23,853,707 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,282 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,030 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 689 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.