Title |
miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1
|
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Published in |
Tumor Biology, November 2015
|
DOI | 10.1007/s13277-015-4425-8 |
Pubmed ID | |
Authors |
Zhiju Zhao, Limei Qin, Shu Li |
Abstract |
Lung cancer is the leading cause of cancer deaths worldwide; the study of microRNAs gives new hope for lung cancer treatment. miR-411 has been demonstrated to be an independent prognostic factor for lung adenocarcinoma, but the role and regulatory mechanism are largely unknown. In the present study, we found miR-411 was overexpressed in the lung cancer cells; overexpression of miR-411 promoted anchorage-dependent and anchorage-independent growths of lung cancer, while miR-411 knockdown reduced this effect. Further study showed forkhead box O1 (FOXO1) was a target of miR-411. Overexpression of miR-411 suppressed the expression of FOXO1; the effect of suppression was abrogated when the mutation occurred in the 3'UTR of FOXO1. Knockdown of FOXO1 in cells which miR-411 was inhibited recapitulated the phenotype of miR-411 overexpression. Taken together, our study revealed miR-411 promoted cell proliferation of lung cancer by targeting tumor suppressor gene FOXO1 and miR-411 might be a potential target for lung cancer therapy. |
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Unknown | 3 | 100% |
Demographic breakdown
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
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Spain | 1 | 5% |
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Demographic breakdown
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Student > Ph. D. Student | 5 | 26% |
Student > Master | 4 | 21% |
Researcher | 3 | 16% |
Student > Bachelor | 2 | 11% |
Professor | 1 | 5% |
Other | 1 | 5% |
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Immunology and Microbiology | 1 | 5% |
Psychology | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 16% |