| Title |
Establishing the Framework for Tissue Engineered Heart Pumps
|
|---|---|
| Published in |
Cardiovascular Engineering and Technology, January 2015
|
| DOI | 10.1007/s13239-015-0211-4 |
| Pubmed ID | |
| Authors |
Mohamed A. Mohamed, Matt K. Hogan, Nikita M. Patel, Ze-Wei Tao, Laura Gutierrez, Ravi K. Birla |
| Abstract |
Development of a natural alternative to cardiac assist devices (CADs) will pave the way to a heart failure therapy which overcomes the disadvantages of current mechanical devices. This work provides the framework for fabrication of a tissue engineered heart pump (TEHP). Artificial heart muscle (AHM) was first fabricated by culturing 4 million rat neonatal cardiac cells on the surface of a fibrin gel. To form a TEHP, AHM was wrapped around an acellular goat carotid artery (GCA) and a chitosan hollow cylinder (CHC) scaffold with either the cardiac cells directly contacting the construct periphery or separated by the fibrin gel. Histology revealed the presence of cardiac cell layer cohesion and adhesion to the fibrin gel scaffold, acellular GCA, and synthesized CHC. Expression of myocytes markers, connexin43 and α-actinin, was also noted. Biopotential measurements revealed the presence of ~2.5 Hz rhythmic propagation of action potential throughout the TEHP. Degradation of the fibrin gel scaffold of the AHM via endogenous proteases may be used as a means of delivering the cardiac cells to cylindrical scaffolds. Further development of the TEHP model by use of multi-stimulus bioreactors may lead to the application of bioengineered CADs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 21% |
| Researcher | 3 | 16% |
| Student > Ph. D. Student | 3 | 16% |
| Student > Master | 2 | 11% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 6 | 32% |
| Medicine and Dentistry | 4 | 21% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Chemical Engineering | 1 | 5% |
| Unknown | 6 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2015.
All research outputs
#18,430,915
of 22,833,393 outputs
Outputs from Cardiovascular Engineering and Technology
#134
of 174 outputs
Outputs of similar age
#257,471
of 353,747 outputs
Outputs of similar age from Cardiovascular Engineering and Technology
#4
of 4 outputs
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