Title |
CXCR4 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma
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Published in |
Annals of Surgical Oncology, November 2015
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DOI | 10.1245/s10434-015-4974-5 |
Pubmed ID | |
Authors |
Masakazu Goto, Takahiro Yoshida, Yota Yamamoto, Yoshihito Furukita, Seiya Inoue, Satoshi Fujiwara, Naoya Kawakita, Takeshi Nishino, Takuya Minato, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Junichi Seike, Yoshimi Bando, Akira Tangoku |
Abstract |
Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The chemokine CXCL12 and its receptors CXCR4 and CXCR7 were suggested to be involved in cancer invasion and metastasis. The aim of this retrospective study was to evaluate the prognostic impact of the expressions of CXCL12, CXCR4 and CXCR7 in patients with esophageal squamous cell carcinoma (ESCC). We used immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate the expressions of CXCL12, CXCR4, and CXCR7 in ESCC patients' tumor biopsy specimens obtained during preoperative endoscopy or surgery. These results were compared with the patients' clinicopathological parameters and survival. IHC was conducted for 172 patients. High expression of CXCR4 in the cytoplasm and nuclei and that of CXCR7 were associated with poor cause-specific survival (CSS) (P= .002 and .010, respectively). The specimens from 52 of the 172 patients were examined by RT-PCR and quantitative real-time PCR. The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumors compared with normal esophageal mucosae (P < .0001). The expression level of mRNA of CXCR4 was associated with poor recurrence-free survival and CSS (P = .012 and .038, respectively). CXCR4 expression is associated with poor prognosis in patients with ESCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 19% |
Professor > Associate Professor | 3 | 11% |
Other | 3 | 11% |
Student > Bachelor | 3 | 11% |
Student > Ph. D. Student | 2 | 7% |
Other | 5 | 19% |
Unknown | 6 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 26% |
Agricultural and Biological Sciences | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Unspecified | 1 | 4% |
Other | 4 | 15% |
Unknown | 7 | 26% |