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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin
|
|---|---|
| Published in |
Cellular and Molecular Gastroenterology and Hepatology, June 2018
|
| DOI | 10.1016/j.jcmgh.2018.06.006 |
| Pubmed ID | |
| Authors |
Brie K. Fuqua, Yan Lu, David M. Frazer, Deepak Darshan, Sarah J. Wilkins, Linda Dunn, Alex V. Loguinov, Scott C. Kogan, Pavle Matak, Huijun Chen, Joshua L. Dunaief, Chris D. Vulpe, Gregory J. Anderson |
| Abstract |
Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3+ carrier transferrin. Hephaestin (HEPH), the only MCF known to be expressed in enterocytes, aids in the basolateral transfer of dietary iron to the blood. Mice lacking HEPH in the whole body (Heph -/- ) or intestine alone (Heph int/int ) exhibit defects in dietary iron absorption but still survive and grow. Circulating ceruloplasmin (CP) is the only other known MCF likely to interact with enterocytes. Our aim was to assess the effects of combined deletion of HEPH and CP on intestinal iron absorption and homeostasis in mice. Mice lacking both HEPH and CP (Heph -/- Cp -/- ) and mice with whole-body knockout of CP and intestine-specific deletion of HEPH (Heph int/int Cp -/- ) were generated and phenotyped. Heph -/- Cp -/- mice were severely anemic and had low serum iron, but they exhibited marked iron loading in duodenal enterocytes, the liver, heart, pancreas, and other tissues. Heph int/int Cp -/- mice were moderately anemic (similar to Cp -/- mice) but were iron loaded only in the duodenum and liver, as in Heph int/int and Cp -/- mice, respectively. Both double knockout models absorbed iron in radiolabeled intestinal iron absorption studies, but the iron was inappropriately distributed, with an abnormally high percentage retained in the liver. These studies indicate that HEPH and CP, and likely MCFs in general, are not essential for intestinal iron absorption but are required for proper systemic iron distribution. They also point to important extra-intestinal roles for HEPH in maintaining whole-body iron homeostasis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Master | 4 | 11% |
| Professor | 3 | 8% |
| Lecturer | 2 | 5% |
| Other | 5 | 14% |
| Unknown | 14 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Neuroscience | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 17 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2018.
All research outputs
#14,605,790
of 25,385,509 outputs
Outputs from Cellular and Molecular Gastroenterology and Hepatology
#677
of 1,143 outputs
Outputs of similar age
#171,113
of 342,125 outputs
Outputs of similar age from Cellular and Molecular Gastroenterology and Hepatology
#12
of 18 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,143 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.