| Title |
A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes
|
|---|---|
| Published in |
Genes & Nutrition, November 2015
|
| DOI | 10.1007/s12263-015-0503-1 |
| Pubmed ID | |
| Authors |
Mitra Hariri, Rasoul Salehi, Awat Feizi, Maryam Mirlohi, Reza Ghiasvand, Nahal Habibi |
| Abstract |
This clinical trial aimed to discover the effects of probiotic soy milk and soy milk on MLH1 and MSH2 promoter methylation, and oxidative stress among type II diabetic patients. Forty patients with type II diabetes mellitus aged 35-68 years were assigned to two groups in this randomized, double-blind, controlled clinical trial. Patients in the intervention group consumed 200 ml/day of probiotic soy milk containing Lactobacillus plantarum A7, while those in the control group consumed 200 ml/d of conventional soy milk for 8 weeks. Fasting blood samples, anthropometric measurements, and 24-h dietary recalls were collected at the baseline and at the end of the study, respectively. Probiotic soy milk significantly decreased promoter methylation in proximal and distal MLH1 promoter region (P < 0.01 and P < 0.0001, respectively) compared with the baseline values, while plasma concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG) decreased significantly compared with soy milk (P < 0.05). In addition, a significant increase in superoxide dismutase (SOD) activity was observed in probiotic soy milk group compared with baseline value (P < 0.01). There were no significant changes from baseline in the promoter methylation of MSH2 within either group (P > 0.05). The consumption of probiotic soy milk improved antioxidant status in type II diabetic patients and may decrease promoter methylation among these patients, indicating that probiotic soy milk is a promising agent for diabetes management. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 15% |
| Student > Master | 17 | 13% |
| Researcher | 16 | 12% |
| Student > Ph. D. Student | 13 | 10% |
| Student > Doctoral Student | 10 | 7% |
| Other | 22 | 16% |
| Unknown | 37 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 21% |
| Agricultural and Biological Sciences | 16 | 12% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Nursing and Health Professions | 11 | 8% |
| Immunology and Microbiology | 5 | 4% |
| Other | 15 | 11% |
| Unknown | 46 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2015.
All research outputs
#15,516,207
of 23,870,022 outputs
Outputs from Genes & Nutrition
#231
of 398 outputs
Outputs of similar age
#218,601
of 393,205 outputs
Outputs of similar age from Genes & Nutrition
#4
of 10 outputs
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