Title |
Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis
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Published in |
European Journal of Nutrition, November 2015
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DOI | 10.1007/s00394-015-1096-6 |
Pubmed ID | |
Authors |
Marianela Vara-Messler, Maria E. Pasqualini, Andrea Comba, Renata Silva, Carola Buccellati, Annalisa Trenti, Lucia Trevisi, Aldo R. Eynard, Angelo Sala, Chiara Bolego, Mirta A. Valentich |
Abstract |
The aim of this study was to determine whether α-linolenic acid (ALA ω-3 fatty acid) enriched diet affects growth parameters when applied to a syngeneic model of mammary carcinoma. BALB/c mice were divided and fed with: 1) a chia oil diet, rich in ALA or 2) a corn oil diet, rich in linoleic acid (LA ω-6 fatty acid). Mice were subcutaneously inoculated with a tumor cell line LM3, derived from a murine mammary adenocarcinoma. After 35 days, tumor incidence, weight, volume and metastasis number were lower in the ALA-fed mice, while tumor latency time was higher, and the release of pro-tumor metabolites derived from ω-6 fatty acids decreased in the tumor. Compared to the control group, a lower number of mitosis, a higher number of apoptotic bodies and higher T-lymphocyte infiltration were consistently observed in the ALA group. An ALA-rich diet decreased the estrogen receptor (ER) α expression, a recognized breast cancer promotor while showing an opposite effect on ERβ in tumor lysates. These data support the anticancer effect of an ALA-enriched diet, which might be used as a dietary strategy in breast cancer prevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 18% |
Student > Master | 9 | 16% |
Professor | 4 | 7% |
Student > Bachelor | 4 | 7% |
Student > Ph. D. Student | 3 | 5% |
Other | 12 | 21% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 19% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Agricultural and Biological Sciences | 8 | 14% |
Nursing and Health Professions | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 1 | 2% |
Unknown | 20 | 35% |