| Title |
Psychotropic treatments in Prader-Willi syndrome: a critical review of published literature
|
|---|---|
| Published in |
European Journal of Pediatrics, November 2015
|
| DOI | 10.1007/s00431-015-2670-x |
| Pubmed ID | |
| Authors |
O. Bonnot, D. Cohen, D. Thuilleaux, A. Consoli, S. Cabal, M. Tauber |
| Abstract |
Prader-Willi syndrome (PWS) is a rare genetic syndrome. The phenotype includes moderate to intellectual disability, dysmorphia, obesity, and behavioral disturbances (e.g., hetero and self-injurious behaviors, hyperphagia, psychosis). Psychotropic medications are widely prescribed in PWS for symptomatic control. We conducted a systematic review of published literature to examine psychotropic medications used in PWS. MEDLINE was searched to identify articles published between January 1967 and December 2014 using key words related to pharmacological treatments and PWS. Articles with original data were included based on a standardized four-step selection process. The identification of studies led to 241 records. All selected articles were evaluated for case descriptions (PWS and behavioral signs) and treatment (type, titration, efficiency, and side effects). Overall, 102 patients were included in these studies. Treatment involved risperidone (three reports, n = 11 patients), fluoxetine (five/n = 6), naltrexone (two/n = 2), topiramate (two/n = 16), fluvoxamine (one/n = 1), mazindol (one/n = 2), N-acetyl cysteine (one/n = 35), rimonabant (one/n = 15), and fenfluramine (one/n = 15). We identified promising treatment effects with topiramate for self-injury and impulsive/aggressive behaviors, risperidone for psychotic symptoms associated with uniparental disomy (UPD), and N-acetyl cysteine for skin picking. The pharmacological approach of behavioral impairment in PWS has been poorly investigated to date. Further randomized controlled studies are warranted. What is Known: • Behavioral disturbances in Prader-Willi syndrome including aggressive reactions, skin picking, and hyperphagia might be very difficult to manage. • Antipsychotic drugs are widely prescribed, but weight gain and increased appetite are their major side effects. What is New: • Topiramate might be efficient for self-injury and impulsive/aggressive behaviors, N-acetyl cysteine is apromising treatment for skin picking and Antidepressants are indicated for OCD symptoms. • Risperidone is indicated in case of psychotic symptoms mainly associated with uniparental disomy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 33% |
| Netherlands | 1 | 33% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 151 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 10% |
| Student > Master | 14 | 9% |
| Researcher | 13 | 8% |
| Student > Doctoral Student | 13 | 8% |
| Student > Ph. D. Student | 11 | 7% |
| Other | 33 | 22% |
| Unknown | 53 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 23% |
| Psychology | 19 | 12% |
| Nursing and Health Professions | 8 | 5% |
| Agricultural and Biological Sciences | 8 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Other | 21 | 14% |
| Unknown | 56 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#16,040,357
of 25,371,292 outputs
Outputs from European Journal of Pediatrics
#2,937
of 4,358 outputs
Outputs of similar age
#216,739
of 399,797 outputs
Outputs of similar age from European Journal of Pediatrics
#25
of 42 outputs
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