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Mendeley readers
Attention Score in Context
| Title |
Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2
|
|---|---|
| Published in |
BMC Genomics, November 2015
|
| DOI | 10.1186/s12864-015-2137-5 |
| Pubmed ID | |
| Authors |
Cinthya J. Zepeda-Mendoza, Swagatam Mukhopadhyay, Emily S. Wong, Nathalie Harder, Erik Splinter, Elzo de Wit, Melanie A. Eckersley-Maslin, Thomas Ried, Roland Eils, Karl Rohr, Alea Mills, Wouter de Laat, Paul Flicek, Anirvan M. Sengupta, David L. Spector |
| Abstract |
Circular chromosome conformation capture (4C) has provided important insights into three dimensional (3D) genome organization and its critical impact on the regulation of gene expression. We developed a new quantitative framework based on polymer physics for the analysis of paired-end sequencing 4C (PE-4Cseq) data. We applied this strategy to the study of chromatin interaction changes upon a 4.3 Mb DNA deletion in mouse region 4E2. A significant number of differentially interacting regions (DIRs) and chromatin compaction changes were detected in the deletion chromosome compared to a wild-type (WT) control. Selected DIRs were validated by 3D DNA FISH experiments, demonstrating the robustness of our pipeline. Interestingly, significant overlaps of DIRs with CTCF/Smc1 binding sites and differentially expressed genes were observed. Altogether, our PE-4Cseq analysis pipeline provides a comprehensive characterization of DNA deletion effects on chromatin structure and function. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| France | 1 | 10% |
| United Kingdom | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 7% |
| China | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 25 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 34% |
| Student > Master | 4 | 14% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Postgraduate | 3 | 10% |
| Student > Bachelor | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 52% |
| Biochemistry, Genetics and Molecular Biology | 8 | 28% |
| Psychology | 2 | 7% |
| Physics and Astronomy | 1 | 3% |
| Unknown | 3 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#6,800,577
of 22,833,393 outputs
Outputs from BMC Genomics
#3,077
of 10,655 outputs
Outputs of similar age
#105,602
of 386,452 outputs
Outputs of similar age from BMC Genomics
#105
of 387 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 10,655 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 387 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.