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Quantifying Progressive Anterior Overgrowth in the Thoracic Vertebrae of Adolescent Idiopathic Scoliosis Patients

Overview of attention for article published in Spine, April 2016
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Title
Quantifying Progressive Anterior Overgrowth in the Thoracic Vertebrae of Adolescent Idiopathic Scoliosis Patients
Published in
Spine, April 2016
DOI 10.1097/brs.0000000000001265
Pubmed ID
Authors

Nicolas Newell, Caroline A. Grant, Bethany E. Keenan, Maree T. Izatt, Mark J. Pearcy, Clayton J. Adam

Abstract

Anterior and posterior vertebral body heights were measured from sequential magnetic resonance imaging (MRI) scans of adolescent idiopathic scoliosis (AIS) patients and healthy controls. To measure changes in vertebral body height over time during scoliosis progression to assess how vertebral body height discrepancies change during growth. Relative anterior overgrowth has been proposed as a potential driver for AIS initiation and progression. This theory proposes that the anterior column grows faster, and the posterior column slower, in AIS patients when compared with healthy controls. There is a disagreement in the literature as to whether the anterior vertebral body heights are proportionally greater than posterior vertebral body heights in AIS patients when compared with healthy controls. To some extent, these discrepancies may be attributed to methodological differences. MRI scans of the major curve of 21 AIS patients (mean age 12.5 ± 1.4 years, mean Cobb 32.2 ± 12.8degree) and between T4 and T12 of 21 healthy adolescents (mean age 12.1 ± 0.5 years) were captured for this study. Of the 21 AIS patients, 14 had a second scan on average 10.8 ± 4.7 months after the first. Anterior and posterior vertebral body heights were measured from the true sagittal plane of each vertebra such that anterior overgrowth could be quantified. The difference between anterior and posterior vertebral body height in healthy, nonscoliotic children was significantly greater than in AIS patients with mild to moderate scoliosis. There was; however, no significant relationship between the overall anterior-posterior vertebral body height difference in AIS and either severity of the curve or its progression over time. Whilst AIS patients have a proportionally longer anterior column than nonscoliotic controls, the degree of anterior overgrowth was not related to the rate of progression or the severity of the scoliotic curve. 3.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 5%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 18%
Researcher 6 15%
Student > Master 4 10%
Other 3 8%
Student > Bachelor 3 8%
Other 8 21%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 14 36%
Engineering 6 15%
Unspecified 3 8%
Business, Management and Accounting 1 3%
Social Sciences 1 3%
Other 3 8%
Unknown 11 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2016.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Spine
#6,653
of 8,450 outputs
Outputs of similar age
#234,500
of 314,718 outputs
Outputs of similar age from Spine
#84
of 139 outputs
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