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Toxicity of silver nanoparticles on different tissues of Balb/C mice

Overview of attention for article published in Life Sciences, September 2018
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Title
Toxicity of silver nanoparticles on different tissues of Balb/C mice
Published in
Life Sciences, September 2018
DOI 10.1016/j.lfs.2018.09.001
Pubmed ID
Authors

Hemen Moradi-Sardareh, Hamid Reza Ghasemi Basir, Zuhair Mohammad Hassan, Maryam Davoudi, Fardin Amidi, Maliheh Paknejad

Abstract

The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice. Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively. Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum. The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 16%
Researcher 6 11%
Student > Master 6 11%
Student > Bachelor 4 7%
Student > Doctoral Student 3 5%
Other 7 13%
Unknown 21 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 14%
Biochemistry, Genetics and Molecular Biology 6 11%
Agricultural and Biological Sciences 4 7%
Chemistry 3 5%
Immunology and Microbiology 3 5%
Other 8 14%
Unknown 24 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#22,767,715
of 25,385,509 outputs
Outputs from Life Sciences
#6,476
of 7,631 outputs
Outputs of similar age
#302,443
of 345,580 outputs
Outputs of similar age from Life Sciences
#61
of 90 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,631 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,580 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.