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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos
|
|---|---|
| Published in |
PLoS Genetics, September 2018
|
| DOI | 10.1371/journal.pgen.1007644 |
| Pubmed ID | |
| Authors |
Ben J. Vincent, Max V. Staller, Francheska Lopez-Rivera, Meghan D. J. Bragdon, Edward C. G. Pym, Kelly M. Biette, Zeba Wunderlich, Timothy T. Harden, Javier Estrada, Angela H. DePace |
| Abstract |
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its target genes, even-skipped (eve). While Hunchback directly represses the eve stripe 3+7 enhancer, we found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression. We also found evidence that Caudal binding sites are responsible for counter-repression, and that this interaction may be a conserved feature of eve stripe 2 enhancers. Our results alter the textbook view of eve stripe 2 regulation wherein Hb is described as a direct activator. Instead, to generate stripe 2, Hunchback repression must be counteracted. We discuss how counter-repression may influence eve stripe 2 regulation and evolution. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 44% |
| United Kingdom | 2 | 13% |
| Switzerland | 1 | 6% |
| Unknown | 6 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 9 | 56% |
| Members of the public | 5 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 28% |
| Researcher | 6 | 13% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Professor | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 43% |
| Agricultural and Biological Sciences | 8 | 17% |
| Physics and Astronomy | 3 | 6% |
| Medicine and Dentistry | 1 | 2% |
| Neuroscience | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 14 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2023.
All research outputs
#3,341,578
of 25,750,437 outputs
Outputs from PLoS Genetics
#2,760
of 8,996 outputs
Outputs of similar age
#63,791
of 347,064 outputs
Outputs of similar age from PLoS Genetics
#54
of 143 outputs
Altmetric has tracked 25,750,437 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,996 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.