| Title |
MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma
|
|---|---|
| Published in |
Acta Neuropathologica, December 2011
|
| DOI | 10.1007/s00401-011-0924-x |
| Pubmed ID | |
| Authors |
Alfa H. C. Bai, Till Milde, Marc Remke, Claudio G. Rolli, Thomas Hielscher, Yoon-Jae Cho, Marcel Kool, Paul A. Northcott, Manfred Jugold, Alexandr V. Bazhin, Stefan B. Eichmüller, Andreas E. Kulozik, Armin Pscherer, Axel Benner, Michael D. Taylor, Scott L. Pomeroy, Ralf Kemkemer, Olaf Witt, Andrey Korshunov, Peter Lichter, Stefan M. Pfister |
| Abstract |
The contribution of microRNAs to the initiation, progression, and metastasis of medulloblastoma (MB) remains poorly understood. Metastatic dissemination at diagnosis is present in about 30% of MB patients, and is associated with a dismal prognosis. Using microRNA expression profiling, we demonstrate that the retinal miR-183-96-182 cluster on chromosome 7q32 is highly overexpressed in non-sonic hedgehog MBs (non-SHH-MBs). Expression of miR-182 and miR-183 is associated with cerebellar midline localization, and miR-182 is significantly overexpressed in metastatic MB as compared to non-metastatic tumors. Overexpression of miR-182 in non-SHH-MB increases and knockdown of miR-182 decreases cell migration in vitro. Xenografts overexpressing miR-182 invaded adjacent normal tissue and spread to the leptomeninges, phenotypically reminiscent of clinically highly aggressive large cell anaplastic MB. Hence, our study provides strong in vitro and in vivo evidence that miR-182 contributes to leptomeningeal metastatic dissemination in non-SHH-MB. We therefore reason that targeted inhibition of miR-182 may prevent leptomeningeal spread in patients with non-SHH-MB. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Czechia | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 76 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 29% |
| Researcher | 14 | 18% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 34% |
| Biochemistry, Genetics and Molecular Biology | 19 | 24% |
| Medicine and Dentistry | 12 | 15% |
| Neuroscience | 9 | 11% |
| Psychology | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 9 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from Acta Neuropathologica
#2,192
of 2,357 outputs
Outputs of similar age
#195,525
of 239,890 outputs
Outputs of similar age from Acta Neuropathologica
#25
of 26 outputs
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