| Title |
Early Behavioral Alterations and Increased Expression of Endogenous Retroviruses Are Inherited Across Generations in Mice Prenatally Exposed to Valproic Acid
|
|---|---|
| Published in |
Molecular Neurobiology, September 2018
|
| DOI | 10.1007/s12035-018-1328-x |
| Pubmed ID | |
| Authors |
Anna Maria Tartaglione, Chiara Cipriani, Flavia Chiarotti, Benedetta Perrone, Emanuela Balestrieri, Claudia Matteucci, Paola Sinibaldi-Vallebona, Gemma Calamandrei, Laura Ricceri |
| Abstract |
Prenatal treatment with the antiepileptic drug valproic acid (VPA) is associated with a significant risk of somatic anomalies, neurodevelopmental delays, and 7-10× increase in the incidence of autism spectrum disorders (ASD) in children. Rodents exposed to VPA in pregnancy show birth defects, deficits in neurodevelopment, and cognitive/social anomalies resembling those of ASD children. Mechanisms of VPA neurobehavioral toxicity are still unclear but as VPA is a non-selective inhibitor of histone deacetylases, epigenetic modifications are likely involved. This study was aimed to evaluate the transgenerational impact of prenatal VPA exposure on mouse early behavioral development, studying F1, F2, and F3 generations after VPA challenge on gestational day (GD) 10.5. We also analyzed in brain and in peripheral blood mononuclear cells the expression levels of different endogenous retrovirus (ERV) families, potential biomarkers of derailed brain development, since human ERVs have been implicated in the pathogenesis of neurodevelopmental disorders (NDDs) such as ASD. Somatic effects of VPA were evident only in F1 generation and more markedly in the female sex. Across F1 and F2 generations, VPA delayed righting reflex, increased motor activity, and reduced ultrasonic vocalizations. The behavioral changes in F3 are milder though in the same direction. VPA increased expression of most ERVs across the three generations in brain and blood. In utero VPA induced neurodevelopmental alterations more marked in the maternal lineage that persisted also in F3, suggesting ERVs as possible downstream effectors of the VPA epigenetic alterations. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Italy | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 16% |
| Student > Ph. D. Student | 11 | 15% |
| Student > Bachelor | 10 | 14% |
| Student > Doctoral Student | 7 | 10% |
| Student > Master | 4 | 5% |
| Other | 7 | 10% |
| Unknown | 22 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Medicine and Dentistry | 8 | 11% |
| Neuroscience | 8 | 11% |
| Agricultural and Biological Sciences | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 25 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#13,389,470
of 23,103,436 outputs
Outputs from Molecular Neurobiology
#1,671
of 3,499 outputs
Outputs of similar age
#166,256
of 336,158 outputs
Outputs of similar age from Molecular Neurobiology
#56
of 119 outputs
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