Title |
Potential therapeutic value of transient receptor potential channels in male urogenital system
|
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Published in |
Pflügers Archiv - European Journal of Physiology, September 2018
|
DOI | 10.1007/s00424-018-2188-y |
Pubmed ID | |
Authors |
Gamze Toktanis, Ecem Kaya-Sezginer, Didem Yilmaz-Oral, Serap Gur |
Abstract |
Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes including light, mechanical or chemical stimuli, temperature, pH, or osmolarity. TRP channel proteins are a diverse family of proteins that are expressed in many tissues. We debated our recent knowledge about the expression, function, and regulation of TRP channels in the different parts of the male urogenital system in health and disease. Emerging evidence suggests that dysfunction of TRP channels significantly contributes to the pathophysiology of urogenital diseases. So far, there are many efforts underway to determine if these channels can be used as drug targets to reverse declines in male urogenital function. Furthermore, developing safe and efficacious TRP channel modulators is warranted for male urogenital disorders in a clinical setting. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 36% |
Professor > Associate Professor | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Researcher | 1 | 9% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Neuroscience | 1 | 9% |
Chemistry | 1 | 9% |
Unknown | 6 | 55% |