Title |
Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances
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Published in |
Forensic Toxicology, November 2015
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DOI | 10.1007/s11419-015-0297-2 |
Pubmed ID | |
Authors |
Zhenhua Qian, Zhendong Hua, Cuimei Liu, Wei Jia |
Abstract |
We identified four cannabimimetic indazole and indole derivatives in new illegal psychoactive substances seized from a clandestine laboratory in China. These four derivatives included N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA, 1), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA, 2), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA, 3), and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA, 4). These compounds were identified by liquid chromatography-high-resolution mass spectrometry, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. No chemical or pharmacological data about compound 4 has appeared until now, making this the first report on this compound. Compounds 1, 2, and 3 have previously been reported to have a high affinity for cannabinoid CB1 and CB2 receptors, but this is the first report of their presence in illegal products. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 10% |
Vietnam | 1 | 10% |
Portugal | 1 | 10% |
United States | 1 | 10% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 12% |
Researcher | 5 | 12% |
Student > Bachelor | 5 | 12% |
Student > Master | 4 | 10% |
Other | 3 | 7% |
Other | 7 | 17% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 10 | 24% |
Medicine and Dentistry | 9 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 3 | 7% |
Unknown | 13 | 32% |