| Title |
MRI versus 68Ga-PSMA PET/CT for gross tumour volume delineation in radiation treatment planning of primary prostate cancer
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, November 2015
|
| DOI | 10.1007/s00259-015-3257-5 |
| Pubmed ID | |
| Authors |
Constantinos Zamboglou, Gesche Wieser, Steffen Hennies, Irene Rempel, Simon Kirste, Martin Soschynski, Hans Christian Rischke, Tobias Fechter, Cordula A. Jilg, Mathias Langer, Philipp T. Meyer, Michael Bock, Anca-Ligia Grosu |
| Abstract |
Multiparametric magnetic resonance imaging (mpMRI) is widely used in radiation treatment planning of primary prostate cancer (PCA). Focal dose escalation to the dominant intraprostatic lesions (DIPL) may lead to improved PCA control. Prostate-specific membrane antigen (PSMA) is overexpressed in most PCAs. (68)Ga-labelled PSMA inhibitors have demonstrated promising results in detection of PCA with PET/CT. The aim of this study was to compare (68)Ga-PSMA PET/CT with MRI for gross tumour volume (GTV) definition in primary PCA. This retrospective study included 22 patients with primary PCA analysed after (68)Ga-PSMA PET/CT and mpMRI. GTVs were delineated on MR images by two radiologists (GTV-MRIrad) and two radiation oncologists separately. Both volumes were merged leading to GTV-MRIint. GTVs based on PET/CT were delineated by two nuclear medicine physicians in consensus (GTV-PET). Laterality (left, right, and left and right prostate lobes) on mpMRI, PET/CT and pathological analysis after biopsy were assessed. Mean GTV-MRIrad, GTV-MRIint and GTV-PET were 5.92, 3.83 and 11.41 cm(3), respectively. GTV-PET was significant larger then GTV-MRIint (p = 0.003). The MRI GTVs GTV-MRIrad and GTV-MRIint showed, respectively, 40 % and 57 % overlap with GTV-PET. GTV-MRIrad and GTV-MRIint included the SUVmax of GTV-PET in 12 and 11 patients (54.6 % and 50 %), respectively. In nine patients (47 %), laterality on mpMRI, PET/CT and histopathology after biopsy was similar. Ga-PSMA PET/CT and mpMRI provided concordant results for delineation of the DIPL in 47 % of patients (40 % - 54 % of lesions). GTV-PET was significantly larger than GTV-MRIint. (68)Ga-PSMA PET/CT may have a role in radiation treatment planning for focal radiation to the DIPL. Exact correlation of PET and MRI images with histopathology is needed. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 2 | 2% |
| Finland | 1 | 1% |
| Unknown | 89 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Other | 14 | 15% |
| Student > Postgraduate | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Student > Ph. D. Student | 6 | 7% |
| Other | 17 | 18% |
| Unknown | 22 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 47% |
| Computer Science | 3 | 3% |
| Engineering | 3 | 3% |
| Agricultural and Biological Sciences | 2 | 2% |
| Nursing and Health Professions | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 34 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2015.
All research outputs
#19,214,418
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#2,305
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Outputs of similar age
#283,640
of 390,388 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#41
of 53 outputs
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