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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
|
|---|---|
| Published in |
Scientific Reports, September 2018
|
| DOI | 10.1038/s41598-018-31659-0 |
| Pubmed ID | |
| Authors |
Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Matthew D. Young, Jorge Berna, Jose M. C. Tubio, Chris E. McMurran, Adam M. H. Young, Mathijs Sanders, Imran Noorani, Stephen J. Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V. Peter Collins, Kieren Allinson, Michael D. Jenkinson, Rasheed Zakaria, Khaja Syed, C. Oliver Hanemann, Jemma Dunn, Michael W. McDermott, Ramez W. Kirollos, George S. Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, Ultan McDermott |
| Abstract |
Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 27% |
| United States | 2 | 18% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Student > Bachelor | 6 | 11% |
| Student > Master | 6 | 11% |
| Researcher | 5 | 9% |
| Other | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 18 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Agricultural and Biological Sciences | 3 | 5% |
| Unspecified | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 7 | 12% |
| Unknown | 25 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2020.
All research outputs
#4,744,243
of 25,378,162 outputs
Outputs from Scientific Reports
#37,013
of 140,112 outputs
Outputs of similar age
#86,611
of 349,110 outputs
Outputs of similar age from Scientific Reports
#1,016
of 3,553 outputs
Altmetric has tracked 25,378,162 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 140,112 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,110 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 3,553 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.