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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers
|
|---|---|
| Published in |
Cancer Cell, September 2018
|
| DOI | 10.1016/j.ccell.2018.08.008 |
| Pubmed ID | |
| Authors |
Pedram Razavi, Matthew T. Chang, Guotai Xu, Chaitanya Bandlamudi, Dara S. Ross, Neil Vasan, Yanyan Cai, Craig M. Bielski, Mark T.A. Donoghue, Philip Jonsson, Alexander Penson, Ronglai Shen, Fresia Pareja, Ritika Kundra, Sumit Middha, Michael L. Cheng, Ahmet Zehir, Cyriac Kandoth, Ruchi Patel, Kety Huberman, Lillian M. Smyth, Komal Jhaveri, Shanu Modi, Tiffany A. Traina, Chau Dang, Wen Zhang, Britta Weigelt, Bob T. Li, Marc Ladanyi, David M. Hyman, Nikolaus Schultz, Mark E. Robson, Clifford Hudis, Edi Brogi, Agnes Viale, Larry Norton, Maura N. Dickler, Michael F. Berger, Christine A. Iacobuzio-Donahue, Sarat Chandarlapaty, Maurizio Scaltriti, Jorge S. Reis-Filho, David B. Solit, Barry S. Taylor, José Baselga |
| Abstract |
We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 tumors previously exposed to hormonal therapy, we identified an increased number of alterations in genes involved in the mitogen-activated protein kinase (MAPK) pathway and in the estrogen receptor transcriptional machinery. Activating ERBB2 mutations and NF1 loss-of-function mutations were more than twice as common in endocrine resistant tumors. Alterations in other MAPK pathway genes (EGFR, KRAS, among others) and estrogen receptor transcriptional regulators (MYC, CTCF, FOXA1, and TBX3) were also enriched. Altogether, these alterations were present in 22% of tumors, mutually exclusive with ESR1 mutations, and associated with a shorter duration of response to subsequent hormonal therapies. |
X Demographics
The data shown below were collected from the profiles of 88 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 37 | 42% |
| United Kingdom | 6 | 7% |
| Italy | 5 | 6% |
| Canada | 3 | 3% |
| Spain | 2 | 2% |
| Australia | 2 | 2% |
| Belgium | 1 | 1% |
| Finland | 1 | 1% |
| Israel | 1 | 1% |
| Other | 5 | 6% |
| Unknown | 25 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 46 | 52% |
| Scientists | 34 | 39% |
| Practitioners (doctors, other healthcare professionals) | 6 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 582 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 582 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 104 | 18% |
| Researcher | 96 | 16% |
| Student > Bachelor | 42 | 7% |
| Student > Master | 37 | 6% |
| Other | 28 | 5% |
| Other | 84 | 14% |
| Unknown | 191 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 162 | 28% |
| Medicine and Dentistry | 102 | 18% |
| Agricultural and Biological Sciences | 45 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 3% |
| Unspecified | 7 | 1% |
| Other | 40 | 7% |
| Unknown | 210 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 167. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2023.
All research outputs
#246,815
of 26,017,215 outputs
Outputs from Cancer Cell
#111
of 3,188 outputs
Outputs of similar age
#5,044
of 349,591 outputs
Outputs of similar age from Cancer Cell
#2
of 43 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,188 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,591 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.