| Title |
Brain 18F-DOPA PET and cognition in de novo Parkinson’s disease
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, March 2015
|
| DOI | 10.1007/s00259-015-3039-0 |
| Pubmed ID | |
| Authors |
Agnese Picco, Silvia Morbelli, Arnoldo Piccardo, Dario Arnaldi, Nicola Girtler, Andrea Brugnolo, Irene Bossert, Lucio Marinelli, Antonio Castaldi, Fabrizio De Carli, Claudio Campus, Giovanni Abbruzzese, Flavio Nobili |
| Abstract |
The role of mesocortical dopaminergic pathways in the cognitive function of patients with early Parkinson's disease (PD) needs to be further clarified. The study groups comprised 15 drug-naive patients with de novo PD and 10 patients with essential tremor (controls) who underwent (18)F-DOPA PET (static acquisition, normalization on mean cerebellar counts) and an extended neuropsychological test battery. Factor analysis with varimax rotation was applied to the neuropsychological test scores, to yield five factors from 16 original scores, which explained 82 % of the total variance. Correlations between cognitive factors and (18)F-DOPA uptake were assessed with SPM8, taking age and gender as nuisance variables. (18)F-DOPA uptake was significantly lower in PD patients than in controls in the bilateral striatum, mainly in the more affected (right) hemisphere, and in a small right temporal region. Significant positive correlations were found only in PD patients between the executive factor and (18)F-DOPA uptake in the bilateral anterior cingulate cortex (ACC) and the middle frontal gyrus, between the verbal fluency factor and (18)F-DOPA uptake in left BA 46 and the bilateral striatum, and between the visuospatial factor and (18)F-DOPA uptake in the left ACC and bilateral striatum. No correlations were found between (18)F-DOPA uptake and either the verbal memory factor or the abstraction-working memory factor. These data clarify the role of the mesocortical dopaminergic pathways in cognitive function in early PD, highlighting the medial frontal lobe, anterior cingulate, and left BA 46 as the main sites of cortical correlation with executive and language functions. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 17% |
| Researcher | 11 | 15% |
| Student > Ph. D. Student | 6 | 8% |
| Student > Bachelor | 4 | 6% |
| Other | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 22 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 27% |
| Psychology | 11 | 15% |
| Neuroscience | 8 | 11% |
| Nursing and Health Professions | 2 | 3% |
| Agricultural and Biological Sciences | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 25 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2015.
All research outputs
#4,412,365
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#476
of 3,083 outputs
Outputs of similar age
#54,023
of 265,244 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#8
of 54 outputs
Altmetric has tracked 23,806,312 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,083 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,244 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.