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Attention Score in Context
| Title |
Alteration of the Metabolome Profile in Endothelial Cells by Overexpression of miR-143/145
|
|---|---|
| Published in |
Journal of microbiology and biotechnology, March 2016
|
| DOI | 10.4014/jmb.1507.07103 |
| Pubmed ID | |
| Authors |
Wenshuo Wang, Ye Yang, Yiqing Wang, Liewen Pang, Jiechun Huang, Hongyue Tao, Xiaotian Sun, Chen Liu |
| Abstract |
The communication between endothelial cell (EC) and smooth muscle cell (SMC) via miR-143/145 cluster is vital to vascular stability. Previous research demonstrates that miR-143/145 released from EC can regulate SMC's proliferation and migration. A recent study finds that SMC also has the capability of manipulating EC's function via miR-143/145. This study artificially increased the expression of miR-143/145 in EC to mimic the similar change caused by miR-143/145 released by SMC and applied untargeted metabolomics analysis, aiming to investigate the consequential effect of miR-143/145 overexpression. Our results show that miR-143/145 overexpression alters the levels of metabolites involved in energy production, DNA methylation and oxidative stress. These changed metabolites indicated that the metabolic pathways，such as SAM cycle and TCA cycle，exhibited significant difference. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 30% |
| Student > Ph. D. Student | 2 | 20% |
| Researcher | 2 | 20% |
| Student > Master | 1 | 10% |
| Student > Postgraduate | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 30% |
| Medicine and Dentistry | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 1 | 10% |
| Nursing and Health Professions | 1 | 10% |
| Veterinary Science and Veterinary Medicine | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 2 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2015.
All research outputs
#22,760,732
of 25,377,790 outputs
Outputs from Journal of microbiology and biotechnology
#903
of 1,259 outputs
Outputs of similar age
#272,560
of 315,686 outputs
Outputs of similar age from Journal of microbiology and biotechnology
#29
of 42 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,259 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.