| Title |
Are lung cysts in renal cell cancer (RCC) patients an indication for FLCN mutation analysis?
|
|---|---|
| Published in |
Familial Cancer, November 2015
|
| DOI | 10.1007/s10689-015-9853-5 |
| Pubmed ID | |
| Authors |
Paul C. Johannesma, Arjan C. Houweling, Fred H. Menko, I. van de Beek, Rinze Reinhard, Johan J. P. Gille, JanHein T. M. van Waesberghe, Erik Thunnissen, Theo M. Starink, Pieter E. Postmus, R. Jeroen A. van Moorselaar |
| Abstract |
Renal cell cancer (RCC) represents 2-3 % of all cancers and is the most lethal of the urologic malignancies, in a minority of cases caused by a genetic predisposition. Birt-Hogg-Dubé syndrome (BHD) is one of the hereditary renal cancer syndromes. As the histological subtype and clinical presentation in BHD are highly variable, this syndrome is easily missed. Lung cysts-mainly under the main carina-are reported to be present in over 90 % of all BHD patients and might be an important clue in differentiating between sporadic RCC and BHD associated RCC. We conducted a retrospective study among patients diagnosed with sporadic RCC, wherein we retrospectively scored for the presence of lung cysts on thoracic CT. We performed FLCN mutation analysis in 8 RCC patients with at least one lung cysts under the carina. No mutations were identified. We compared the radiological findings in the FLCN negative patients to those in 4 known BHD patients and found multiple basal lung cysts were present significantly more frequent in FLCN mutation carriers and may be an indication for BHD syndrome in apparent sporadic RCC patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 27% |
| Researcher | 3 | 20% |
| Student > Bachelor | 2 | 13% |
| Professor | 1 | 7% |
| Other | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 53% |
| Biochemistry, Genetics and Molecular Biology | 1 | 7% |
| Psychology | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Unknown | 4 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2015.
All research outputs
#1,964,309
of 22,834,308 outputs
Outputs from Familial Cancer
#20
of 558 outputs
Outputs of similar age
#35,124
of 386,693 outputs
Outputs of similar age from Familial Cancer
#2
of 14 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 558 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.