| Title |
Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas
|
|---|---|
| Published in |
European Journal of Nutrition, November 2015
|
| DOI | 10.1007/s00394-015-1103-y |
| Pubmed ID | |
| Authors |
Noor Fatima, Rahman M. Hafizur, Abdul Hameed, Shakil Ahmed, Maliha Nisar, Nurul Kabir |
| Abstract |
The present study was undertaken to explore the possible anti-diabetic mechanism(s) of Emblica officinalis (EO) and its active constituent, ellagic acid (EA), in vitro and in vivo. Neonatal streptozotocin-induced non-obese type 2 diabetic rats were treated with a methanolic extract of EO (250 or 500 mg/kg) for 28 days, and blood glucose, serum insulin, and plasma antioxidant status were measured. Insulin and glucagon immunostaining and morphometry were performed in pancreatic section, and liver TBARS and GSH levels were measured. Additionally, EA was tested for glucose-stimulated insulin secretion and glucose tolerance test. Treatment with EO extract resulted in a significant decrease in the fasting blood glucose in a dose- and time-dependent manner in the diabetic rats. It significantly increased serum insulin in the diabetic rats in a dose-dependent manner. Insulin-to-glucose ratio was also increased by EO treatment. Immunostaining of pancreas showed that EO250 increased β-cell size, but EO500 increased β-cells number in diabetic rats. EO significantly increased plasma total antioxidants and liver GSH and decreased liver TBARS. EA stimulated glucose-stimulated insulin secretion from isolated islets and decreased glucose intolerance in diabetic rats. Ellagic acid in EO exerts anti-diabetic activity through the action on β-cells of pancreas that stimulates insulin secretion and decreases glucose intolerance. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 14% |
| Researcher | 13 | 13% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 4 | 4% |
| Other | 15 | 15% |
| Unknown | 38 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Agricultural and Biological Sciences | 6 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 12 | 12% |
| Unknown | 49 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#2,194,606
of 23,532,144 outputs
Outputs from European Journal of Nutrition
#541
of 2,453 outputs
Outputs of similar age
#37,790
of 389,664 outputs
Outputs of similar age from European Journal of Nutrition
#17
of 58 outputs
Altmetric has tracked 23,532,144 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,453 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.2. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.