| Title |
Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis
|
|---|---|
| Published in |
Brain Topography, November 2015
|
| DOI | 10.1007/s10548-015-0465-z |
| Pubmed ID | |
| Authors |
Roee Holtzer, Joe Verghese, Gilles Allali, Meltem Izzetoglu, Cuiling Wang, Jeannette R. Mahoney |
| Abstract |
The posture first hypothesis suggests that under dual-task walking conditions older adults prioritize gait over cognitive task performance. Functional neural confirmation of this hypothesis, however, is lacking. Herein, we determined the functional neural correlates of the posture first hypothesis and hypothesized that the presence of neurological gait abnormalities (NGA) would moderate associations between brain activations, gait and cognitive performance. Using functional near-infrared spectroscopy we assessed changes in oxygenated hemoglobin levels in the pre-frontal cortex (PFC) during normal walk and walk while talk (WWT) conditions in a large cohort of non-demented older adults (n = 236; age = 75.5 ± 6.49 years; female = 51.7 %). NGA were defined as central (due to brain diseases) or peripheral (neuropathic gait) following a standardized neurological examination protocol. Double dissociations between brain activations and behavior emerged as a function of NGA. Higher oxygenation levels during WWT were related to better cognitive performance (estimate = 0.145; p < 0.001) but slower gait velocity (estimate = -6.336, p < 0.05) among normals. In contrast, higher oxygenation levels during WWT among individuals with peripheral NGA were associated with worse cognitive performance (estimate = -0.355; p < 0.001) but faster gait velocity (estimate = 14.855; p < 0.05). Increased activation in the PFC during locomotion may have a compensatory function that is designed to support gait among individuals with peripheral NGA. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 23% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 11 | 10% |
| Researcher | 11 | 10% |
| Student > Doctoral Student | 6 | 5% |
| Other | 15 | 13% |
| Unknown | 29 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 18% |
| Medicine and Dentistry | 14 | 12% |
| Sports and Recreations | 10 | 9% |
| Psychology | 10 | 9% |
| Nursing and Health Professions | 6 | 5% |
| Other | 13 | 12% |
| Unknown | 40 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2015.
All research outputs
#15,351,145
of 22,834,308 outputs
Outputs from Brain Topography
#304
of 487 outputs
Outputs of similar age
#227,035
of 387,438 outputs
Outputs of similar age from Brain Topography
#3
of 7 outputs
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