| Title |
Xist regulation and function eXplored
|
|---|---|
| Published in |
Human Genetics, May 2011
|
| DOI | 10.1007/s00439-011-1008-7 |
| Pubmed ID | |
| Authors |
Daphne B. Pontier, Joost Gribnau |
| Abstract |
X chromosome inactivation (XCI) is a process in mammals that ensures equal transcript levels between males and females by genetic inactivation of one of the two X chromosomes in females. Central to XCI is the long non-coding RNA Xist, which is highly and specifically expressed from the inactive X chromosome. Xist covers the X chromosome in cis and triggers genetic silencing, but its working mechanism remains elusive. Here, we review current knowledge about Xist regulation, structure, function and conservation and speculate on possible mechanisms by which its action is restricted in cis. We also discuss dosage compensation mechanisms other than XCI and how knowledge from invertebrate species may help to provide a better understanding of the mechanisms of mammalian XCI. |
Mendeley readers
The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 238 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 66 | 27% |
| Student > Master | 43 | 17% |
| Student > Bachelor | 37 | 15% |
| Researcher | 27 | 11% |
| Student > Postgraduate | 11 | 4% |
| Other | 31 | 13% |
| Unknown | 31 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 99 | 40% |
| Biochemistry, Genetics and Molecular Biology | 76 | 31% |
| Medicine and Dentistry | 15 | 6% |
| Immunology and Microbiology | 7 | 3% |
| Engineering | 5 | 2% |
| Other | 12 | 5% |
| Unknown | 32 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2021.
All research outputs
#2,918,113
of 22,659,164 outputs
Outputs from Human Genetics
#260
of 2,948 outputs
Outputs of similar age
#14,305
of 111,242 outputs
Outputs of similar age from Human Genetics
#4
of 38 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,948 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.