| Title |
Thermal Magnetic Field Activated Propolis Release From Liquid Crystalline System Based on Magnetic Nanoparticles
|
|---|---|
| Published in |
AAPS PharmSciTech, September 2018
|
| DOI | 10.1208/s12249-018-1163-4 |
| Pubmed ID | |
| Authors |
Lucas de Alcântara Sica de Toledo, Hélen Cássia Rosseto, Rafaela Said dos Santos, Federico Spizzo, Lucia Del Bianco, Maiara Camotti Montanha, Elisabetta Esposito, Elza Kimura, Patricia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski, Rita Cortesi, Marcos Luciano Bruschi |
| Abstract |
Intra-periodontal pocket drug delivery systems, such as liquid crystalline systems, are widely utilized improving the drug release control and the therapy. Propolis is used in the treatment of periodontal diseases, reducing the inflammatory and infectious conditions. Iron oxide magnetic nanoparticles (MNPs) can improve the treatment when an alternating external magnetic field (AEMF) is applied, increasing the local temperature. The aim of this study was to develop a liquid crystalline system containing MNPs for intra-periodontal pocket propolis release. MNPs were prepared using iron salts and the morphological, size, thermal, x-ray diffraction, magnetometry, and Mössbauer spectroscopy analyses were performed. Cytotoxicity studies using Artemia salina and fibroblasts were also accomplished. The systems were prepared using polyoxyethylene (10) oleyl ether, isopropyl myristate, purified water, and characterized by polarized optical microscopy, rheometry, and in vitro drug release profile using a periodontal pocket simulator apparatus. The antifungal activity of the systems was investigated against Candida spp. using an AEMF. MNPs displayed nanometric size, were monodisperse, and they displayed very low cytotoxicity. Microscopically homogeneous formulations were obtained displaying important physicochemical and biological properties. The system displayed prolonged release of propolis and important in vitro fungicide activity, which was increased when the AEMF was applied, indicating a potentially alternative therapy for the treatment of the periodontal disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 15% |
| Student > Master | 6 | 13% |
| Student > Ph. D. Student | 5 | 11% |
| Researcher | 4 | 9% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 16 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 15% |
| Medicine and Dentistry | 5 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Agricultural and Biological Sciences | 4 | 9% |
| Immunology and Microbiology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 23 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2018.
All research outputs
#17,990,045
of 23,103,436 outputs
Outputs from AAPS PharmSciTech
#1,183
of 1,480 outputs
Outputs of similar age
#242,227
of 337,668 outputs
Outputs of similar age from AAPS PharmSciTech
#9
of 18 outputs
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