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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
|
|---|---|
| Published in |
Nature Communications, December 2015
|
| DOI | 10.1038/ncomms9983 |
| Pubmed ID | |
| Authors |
Michelle A. Lawson, Michelle M. McDonald, Natasa Kovacic, Weng Hua Khoo, Rachael L. Terry, Jenny Down, Warren Kaplan, Julia Paton-Hough, Clair Fellows, Jessica A. Pettitt, T. Neil Dear, Els Van Valckenborgh, Paul A. Baldock, Michael J. Rogers, Colby L. Eaton, Karin Vanderkerken, Allison R. Pettit, Julian M. W. Quinn, Andrew C. W. Zannettino, Tri Giang Phan, Peter I. Croucher |
| Abstract |
Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal niche, enter a dormant state and subsequently become activated to form colonies. We demonstrate that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched 'off' by osteoclasts remodelling the endosteal niche. Dormant myeloma cells are resistant to chemotherapy that targets dividing cells. The demonstration that the endosteal niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell-extrinsic mechanisms to overcome cell-intrinsic drug resistance and prevent disease relapse. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 57% |
| Canada | 1 | 14% |
| Australia | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 251 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Belgium | 1 | <1% |
| Unknown | 248 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 24% |
| Researcher | 42 | 17% |
| Student > Master | 27 | 11% |
| Student > Bachelor | 22 | 9% |
| Student > Doctoral Student | 15 | 6% |
| Other | 32 | 13% |
| Unknown | 54 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 24% |
| Medicine and Dentistry | 44 | 18% |
| Agricultural and Biological Sciences | 39 | 16% |
| Engineering | 12 | 5% |
| Immunology and Microbiology | 9 | 4% |
| Other | 24 | 10% |
| Unknown | 63 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2024.
All research outputs
#596,982
of 25,460,914 outputs
Outputs from Nature Communications
#10,292
of 57,172 outputs
Outputs of similar age
#9,827
of 395,775 outputs
Outputs of similar age from Nature Communications
#147
of 654 outputs
Altmetric has tracked 25,460,914 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,172 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 654 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.